For decades, scientists have assumed that chronic inflammation—often called inflammaging—is a universal hallmark of human aging. Elevated inflammatory markers like IL-6, TNF-α, and CRP have been associated with age-related diseases including Alzheimer’s, diabetes, cardiovascular disease, and chronic kidney disease. But a groundbreaking new study published in Nature Aging on June 30, challenges this prevailing assumption.The researchers suggest that what we currently define as inflammaging may not be a biological imperative but rather a context-specific phenomenon. In industrialized societies, chronic inflammation likely arises from a confluence of factors—sedentary lifestyles, processed diets, psychosocial stress, pollution, disrupted circadian rhythms, and altered microbiomes.
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